DO NOT take the NEW road. It is long from being completed. I did it in December on a 4WD truck. It took as long and it was much more treacherous than the main road.
The trip from Santo Domingo to Samana is 5 1/2 hrs. My best advise is to fly. A friend flies regularly to Las Terrenas from La Isabela airport. The cost is around $50. I am looking for the airline information myself.
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