The best route is Sosua east to Nagua....along the north coast highway, then south on the new highway, then east from santo domingo to punta cana on the south coast highway, going through higuey. Without stops should take you about 5-6 hours. The drive from Sosua to Nagua and Nagua to SD are quite scenic and from SD to PC there are plenty of places to stop and/or stay...several beach towns along the route...boca chica, juan dolio, bayahibe, etc...
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