There is no direct route to get to Samana.
Departing from Boca Chica, you have to go to Santo Domingo, drive through the city on 27 de feb. avenue, make a right on Maximo Gomez, Churchil ave. or Lincoln and a right on JFKennedy avenue, then is all straight 'till you hook up with Autopista Duarte. Pay the toll and 15 pesos later, drive straight Villa Altagracia and Bonao then turn to San Francisco de Macoris then Nagua and you're on the final stretch towards Samana.
From Boca Chica, the trip should take between 3.30-4.30 hours depending on the traffic while crossing StoDgo and later San Francisco.
I highly recommend buying a road map (at least one that shows the main roads and highways) and travelling in the morning(safer and less traffic).
In samana, where do you want to stay? Las Terrenas, Galeras, Samana city?
In Las Galeras, check out Club Bonito or Villa Serena. I think youd also like Costa Las Ballenas and Atlantis hotel near Las Terrenas.
Hope this helps.
Have a Good Trip!
