To do it on the cheap it would take you almost a day to get there and another day to get back. Better plan on a return trip to the DR and stay in Samana; it will be worth the return trip.
I you want to lose the two days -- take an Expreso Bavaro bus to Santo Domingo (4 hours). Get a RD$150 cab drive to Caribe Tours (1/2 hour). Take the Caribe Tours bus to Samana city (4 hours). All in all will cost you about US$20, but again it will take you a day to go and come back. In my opinion, there is so much more you could do in the Bavaro area -- better to visit Boca de Yuma, see the house of Ponce de Leon, take a boat trip up the river and visit La Playita, for instance. Do the waterhole tour of Punta Cana, contact through the Punta Cana Ecological Foundation. Rent a car and drive up to Macao beach.
To go via El Seibo-Sabana de la Mar will also take you pretty much of a day. To El Seibo it is about two-three hours. And then you have to catch the ferry -- about two three hours.
Better to stay at the Cano Hondo-Paraiso hotel and do the eco walks from there, instead of the extra trip to Samana.
My recommendation is that you leave that for another trip.
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